UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Medicinal benefits of Nigella sativa in bronchial asthma: A literature review

Koshak, A; Koshak, E; Heinrich, M; (2017) Medicinal benefits of Nigella sativa in bronchial asthma: A literature review. Saudi Pharmaceutical Journal , 25 (8) pp. 1130-1136. 10.1016/j.jsps.2017.07.002. Green open access

[img]
Preview
Text
Heinrich_Medicinal benefits of Nigella sativa in bronchial asthma. A literature review_VoR.pdf

Download (385kB) | Preview

Abstract

Nigella sativa L. (NS) seeds, known as black seed, is a spice and a traditional herbal medicine used in various diseases including bronchial asthma. This review aimed to assess the studies supporting the medicinal use of NS in asthma and to highlight future research priorities. Various medical databases were searched for the effects of NS and its active secondary metabolites in asthma inflammation and outcomes. There were fourteen preclinical studies describing multiple effects of NS in animal or cellular models of asthma including bronchodilation, anti-histaminic, anti-inflammatory, anti-leukotrienes and immunomodulatory effects. Furthermore, seven clinical studies showed improvements in different asthma outcomes including symptoms, pulmonary function and laboratory parameters. However, often these studies are small and used ill-defined preparations. In conclusion, NS could be therapeutically beneficial in alleviating airway inflammation and the control of asthma symptoms, but the evidence remains scanty and is often based on poorly characterised preparations. Accordingly, well-designed large clinical studies using chemically well characterised NS preparation are required.

Type: Article
Title: Medicinal benefits of Nigella sativa in bronchial asthma: A literature review
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jsps.2017.07.002
Publisher version: https://doi.org/10.1016/j.jsps.2017.07.002
Language: English
Additional information: © 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Nigella sativa, Black seed, Asthma, Traditional medicine, Clinical studies
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1567715
Downloads since deposit
350Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item