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Unmyelinated Peripheral Nerves Can Be Stimulated in Vitro Using Pulsed Ultrasound

Wright, CJ; Haqshenas, SR; Rothwell, J; Saffari, N; (2017) Unmyelinated Peripheral Nerves Can Be Stimulated in Vitro Using Pulsed Ultrasound. Ultrasound in Medicine & Biology , 43 (10) pp. 2269-2283. 10.1016/j.ultrasmedbio.2017.05.008. Green open access

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Abstract

Appreciation for the medical and research potential of ultrasound neuromodulation is growing rapidly, with potential applications in non-invasive treatment of neurodegenerative disease and functional brain mapping spurring recent progress. However, little progress has been made in our understanding of the ultrasound–tissue interaction. The current study tackles this issue by measuring compound action potentials (CAPs) from an ex vivo crab walking leg nerve bundle and analysing the acoustic nature of successful stimuli using a passive cavitation detector (PCD). An unimpeded ultrasound path, new acoustic analysis techniques and simple biological targets are used to detect different modes of cavitation and narrow down the candidate biological effectors with high sensitivity. In the present case, the constituents of unmyelinated axonal tissue alone are found to be sufficient to generate de novo action potentials under ultrasound, the stimulation of which is significantly correlated to the presence of inertial cavitation and is never observed in its absence.

Type: Article
Title: Unmyelinated Peripheral Nerves Can Be Stimulated in Vitro Using Pulsed Ultrasound
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ultrasmedbio.2017.05.008
Publisher version: https://doi.org/10.1016/j.ultrasmedbio.2017.05.008
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Technology, Life Sciences & Biomedicine, Acoustics, Radiology, Nuclear Medicine & Medical Imaging, Neurostimulation, Neuromodulation, In Vitro, Peripheral Nerves, Therapeutic Ultrasound, Cavitation, Axons, Transcranial Focused Ultrasound, Primary Somatosensory Cortex, Brain-Stimulation, Vivo Neurostimulation, Evoked-Potentials, Cavitation, Humans, Tissue, Skin, Neuromodulation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1567704
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