UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

A Model-Based Support for Diagnosing von Willebrand Disease

Castaldello, C; Gubert, A; Galvanin, F; Casonato, A; Padrini, R; Barolo, M; Bezzo, M; (2017) A Model-Based Support for Diagnosing von Willebrand Disease. In: Computer Aided Chemical Engineering. (pp. pp. 2779-2784). Elsevier: Barcelona, Spain.

[thumbnail of 3041_final.pdf] Text
3041_final.pdf - Accepted Version
Access restricted to UCL open access staff

Download (349kB)

Abstract

Von Willebrand disease (VWD) is the most common inherited bleeding disease and is caused by deficiency or dysfunction of a multimeric glycoprotein, namely the von Willebrand factor (VWF). The disease is present in numerous subtypes, making the diagnosis through the classic 24-h DDAVP sampling protocol a difficult task. In this simulation study, a new simplified pharmacokinetic model is proposed with the aims of demonstrating that a shorter DDAVP clinical test can be devised and that indices, such as clearance, total amount of VWF released and multimeric ratio at basal state can be exploited with multivariate classification methods in order to help practitioners to reach a correct diagnosis.

Type: Proceedings paper
Title: A Model-Based Support for Diagnosing von Willebrand Disease
Event: ESCAPE 27 - 27th European Symposium on Computer Aided Process Engineering
Location: Barcelona
Dates: 01 October 2017 - 05 October 2017
DOI: 10.1016/B978-0-444-63965-3.50465-7
Publisher version: https://doi.org/10.1016/B978-0-444-63965-3.50465-7
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: von Willebrand disease, physiological model, model-based diagnosis, personalised medicine
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1566834
Downloads since deposit
1Download
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item