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Suppression of CD36 attenuates adipogenesis with a reduction of P2X7 expression in 3T3-L1 cells

Gao, H; Li, D; Yang, P; Zhao, L; Wei, L; Chen, Y; Ruan, XZ; (2017) Suppression of CD36 attenuates adipogenesis with a reduction of P2X7 expression in 3T3-L1 cells. Biochemical and Biophysical Research Communications 10.1016/j.bbrc.2017.07.077. Green open access

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Abstract

Adipogenesis is a process of differentiation from preadipocyte into adipocyte, and is regulated by several transcription factors, including the peroxisome proliferator-activated receptor gamma (PPARγ) and the CCAAT-enhancer-binding protein alpha (C/EBPα). CD36 is a membrane protein which contributes to the metabolic disorders such as obesity. Although the previous study demonstrated CD36 participated in the progression of adipogenesis, the mechanism is still unclear. We report here that knockdown of CD36 expression by CD36 small interfering RNA (siRNA) resulted in a reduction of adipocyte differentiation and adipogenic protein expression. In addition, purinergic receptor P2X, ligand-gated ion channel 7 (P2X7) was downregulated in CD36-knockdown 3T3-L1 cells, suggesting that the suppression of CD36 attenuates adipogenesis via the P2X7 pathway in 3T3-L1 cells.

Type: Article
Title: Suppression of CD36 attenuates adipogenesis with a reduction of P2X7 expression in 3T3-L1 cells
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bbrc.2017.07.077
Publisher version: http://doi.org/10.1016/j.bbrc.2017.07.077
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: CD36; Adipogenesis; ATP; P2X7
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1565262
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