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Aggregatibacter actinomycetemcomitans serotype prevalence and antibiotic resistance in a UK population with periodontitis

Akrivopoulou, C; Green, IM; Donos, N; Nair, SP; Ready, D; (2017) Aggregatibacter actinomycetemcomitans serotype prevalence and antibiotic resistance in a UK population with periodontitis. Journal of Global Antimicrobial Resistance , 10 pp. 54-58. 10.1016/j.jgar.2017.03.011. Green open access

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Abstract

OBJECTIVES: Aggregatibacter actinomycetemcomitans is a recognised pathogen involved in aggressive periodontitis. Seven serotypes of A. actinomycetemcomitans exist with a range of virulence and distribution dependent on ethnicity and geography. The ability of A. actinomycetemcomitans to invade soft tissue can necessitate the use of systemic antibiotics for treatment, however variations in its antibiotic susceptibility exist dependent on geographical location. METHODS: Serotypes of A. actinomycetemcomitans isolates from a UK cohort of 50 patients with aggressive periodontitis were determined by PCR. Resistance of the isolates to eight antibiotics [penicillin (1 U), amoxicillin (2 μg), amoxicillin/clavulanic acid (30 μg), metronidazole (5 μg), clindamycin (2 μg), tetracycline (10 μg), ciprofloxacin (5 μg) and ceftazidime (30 μg)] were determined by disk diffusion according to BSAC guidelines. RESULTS: Prevalences of serotypes a, c, b, e and mixed serotypes were 48%, 22%, 2%, 2% and 12%, respectively. The serotype of isolates from seven patients (14%) could not be deduced by PCR. Of the 56 isolates tested, 100% were resistant to penicillin and metronidazole, 87.5% to clindamycin, 83.9% to amoxicillin and 76.8% to ceftazidime. Low rates of resistance to tetracycline (8.9% resistant) and amoxicillin/clavulanic acid (14.3% resistant) were observed, whereas no isolates were resistant to ciprofloxacin. CONCLUSIONS: As in a number of publications the suggested treatment of aggressive periodontitis includes the combined use of amoxicillin with metronidazole, these results highlight the need for culture and antimicrobial susceptibility investigations in patients with aggressive periodontitis prior to systemic use of antibiotics concomitantly to periodontal therapy.

Type: Article
Title: Aggregatibacter actinomycetemcomitans serotype prevalence and antibiotic resistance in a UK population with periodontitis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jgar.2017.03.011
Publisher version: https://doi.org/10.1016/j.jgar.2017.03.011
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, Pharmacology & Pharmacy, Periodontitis, Aggregatibacter Actinomycetemcomitans, Antibiotic Susceptibility, Antibiotic Resistance, Serotype, United Kingdom, Vitro Antimicrobial Susceptibility, Actinobacillus-Actinomycetemcomitans, Aggressive Periodontitis, Juvenile Periodontitis, Pathogens, Bacteria, Strains, Profiles, Therapy, Plaque
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1564076
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