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Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue

Grootendorst, MR; Fitzgerald, AJ; de Koning, SGB; Santaolalla, A; Portieri, A; Van Hemelrijck, M; Young, MR; ... Purushotham, A; + view all (2017) Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue. Biomedical Optics Express , 8 (6) pp. 2932-2945. 10.1364/BOE.8.002932. Green open access

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Abstract

Since nearly 20% of breast-conserving surgeries (BCS) require re-operation, there is a clear need for developing new techniques to more accurately assess tumor resection margins intraoperatively. This study evaluates the diagnostic accuracy of a handheld terahertz pulsed imaging (TPI) system to discriminate benign from malignant breast tissue ex vivo. Forty six freshly excised breast cancer samples were scanned with a TPI handheld probe system, and histology was obtained for comparison. The image pixels on TPI were classified using (1) parameters in combination with support vector machine (SVM) and (2) Gaussian wavelet deconvolution in combination with Bayesian classification. The results were an accuracy, sensitivity, specificity of 75%, 86%, 66% for method 1, and 69%, 87%, 54% for method 2 respectively. This demonstrates the probe can discriminate invasive breast cancer from benign breast tissue with an encouraging degree of accuracy, warranting further study.

Type: Article
Title: Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue
Open access status: An open access version is available from UCL Discovery
DOI: 10.1364/BOE.8.002932
Publisher version: http://doi.org/10.1364/BOE.8.002932
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1563885
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