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The power of bioluminescence imaging in understanding host-pathogen interactions

Suff, N; Waddington, SN; (2017) The power of bioluminescence imaging in understanding host-pathogen interactions. Methods , 127 pp. 69-78. 10.1016/j.ymeth.2017.07.001. Green open access

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Abstract

Infectious diseases are one of the leading causes of death worldwide. Modelling and understanding human infection is imperative to developing treatments to reduce the global burden of infectious disease. Bioluminescence imaging is a highly sensitive, non-invasive technique based on the detection of light, produced by luciferase-catalysed reactions. In the study of infectious disease, bioluminescence imaging is a well-established technique; it can be used to detect, localize and quantify specific immune cells, pathogens or immunological processes. This enables longitudinal studies in which the spectrum of the disease process and its response to therapies can be monitored. Light producing transgenic rodents are emerging as key tools in the study of host response to infection. Here, we review the strategies for identifying biological processes in vivo, including the technology of bioluminescence imaging and illustrate how this technique is shedding light on the host-pathogen relationship.

Type: Article
Title: The power of bioluminescence imaging in understanding host-pathogen interactions
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ymeth.2017.07.001
Publisher version: http://doi.org/10.1016/j.ymeth.2017.07.001
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Bioluminescence, Biosensor, Gene transfer, Host-pathogen relationship, Transcription factor
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1563633
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