UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Development of a hydroxyapatite/POSS-PCU composite film for bone grafting and augmentation

Salmasi, S; (2017) Development of a hydroxyapatite/POSS-PCU composite film for bone grafting and augmentation. Doctoral thesis , UCL (University College London). Green open access

[thumbnail of Salmasi PhD Thesis- Revised June 2017.pdf]
Preview
Text
Salmasi PhD Thesis- Revised June 2017.pdf - Accepted Version

Download (9MB) | Preview

Abstract

The current approach towards treating critical size bone defects, with the aim of repairing or regenerating bone, is the use of bone grafts (autografts or allografts). However, due to various disadvantages associated with the use of autografts and allografts, biomaterials; synthetic ceramic/polymer composites as bone grafts substitutes and guided bone regeneration membranes in particular, have been recognised as effective alternatives to the traditional methods. Polyhedral oligomeric silsesquioxane covalently bonded to poly(carbonate- urea-urethane), (POSS-PCU), a novel co-polymer, has displayed improved physico-chemical and material-cell interaction properties, which have led to variety of investigations on clinical applications of this material such as in synthetic heart valve production, bypass grafts, POSS-PCU coated stents and biomaterial scaffolds. In this thesis, hydroxyapatite incorporated POSS-PCU composite films were developed and examined for the purpose of bone grafting and augmentation. Various concentrations of hydroxyapatite, filler integration and fabrication techniques as well as in vitro models were used to find the most suitable HA/POSS-PCU based composite film that has a closer characteristics to natural bone and enhances bone repair and new bone formation for bone grafting and augmentation applications. It was shown that hydroxyapatite has a concentration-dependent effect on the physico-chemical and material-cell interaction properties of POSS-PCU. In addition, it was shown that hydroxyapatite particles were exposed on the surface of the 50 wt% HA/POSS-PCU composite films and enhanced the bioactivity of these composite films in simulated body fluid. Finally, optimisation of the samples using surface solvent etching and porosity showed that the former increased surface hydrophobicity and reduced mechanical properties of both HA incorporated and HA free POSS-PCU films. Amongst all of the HA/POSS-PCU based composite films investigated here porous 50 wt% HA/POSS-PCU composites showed the most enhanced material-cell interaction properties. In conclusion, HA/POSS-PCU composites have the potential to be further investigated for bone augmentation as guided bone regeneration membranes.

Type: Thesis (Doctoral)
Title: Development of a hydroxyapatite/POSS-PCU composite film for bone grafting and augmentation
Event: DIVISION OF SURGERY AND INTERVENTIONAL SCIENCE
Open access status: An open access version is available from UCL Discovery
Language: English
Keywords: Hydroxyapatite, composite, bone
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/1563547
Downloads since deposit
128Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item