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Regional differences in presentation of AIDS in Europe

Blaxhult, A; Kirk, O; Pedersen, C; Dietrich, M; Barton, SE; Gatell, JM; Mulcahy, F; ... Lundgren, JD; + view all (2000) Regional differences in presentation of AIDS in Europe. Epidemiology and Infection , 125 (1) 143 - 151. Green open access

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Abstract

Data were collected on 6578 patients diagnosed with AIDS at 52 clinical centres in 17 European countries during an Ii-year period from 1979 to 1989. The centres were divided into four regions, North, Central, Southeast, and Southwest. Differences in the incidence of most AIDS-defining opportunistic infections and malignancies were found. After adjusting for known possible confounders, statistically significant differences between regions remained. Pneumocystis carinii pneumonia (PCP) was more common in Northern Europe, Kaposi's sarcoma and toxoplasmosis in Central Europe, cytomegalovirus retinitis in South-eastern Europe, and extrapulmonary tuberculosis in South-western Europe. These differences we attribute primarily to different degrees of exposure to the respective underlying pathogens. The prevalence of these and other micro-organisms will determine the clinical course of HIV infections in parts of Eastern Europe and elsewhere where the virus now is spreading

Type: Article
Title: Regional differences in presentation of AIDS in Europe
Open access status: An open access version is available from UCL Discovery
Publisher version: http://journals.cambridge.org/action/displayAbstra...
Language: English
Additional information: © 2000 Cambridge University Press
Keywords: AIDS, clinical, COHORT, COMMON, Cytomegalovirus, DEATH, difference, disease, DURATION, Eastern Europe, English, epidemiology, Europe, european, EXPOSURE, Hiv, HIV INFECTION, HIV Infections, HIV-INFECTED PATIENTS, HIV-INFECTION, IMMUNE-DEFICIENCY-SYNDROME, Incidence, Infection, INFECTIONS, Ireland, Kaposi's sarcoma, MALIGNANCIES, MED, NORTH, Opportunistic Infections, Patient, patients, Pneumonia, Prevalence, REGION, regions, Spain, SURVIVAL, SWEDEN, tuberculosis, VIRUS, ZIDOVUDINE BENEFIT
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
URI: https://discovery.ucl.ac.uk/id/eprint/156345
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