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Abnormal Retinal Reflectivity To Short-Wavelength Light In Type 2 Idiopathic Macular Telangiectasia

Sallo, FB; Leung, I; Zeimer, M; Clemons, TE; Dubis, AM; Fruttiger, M; Pauleikhoff, D; ... MacTel Study Group; + view all (2018) Abnormal Retinal Reflectivity To Short-Wavelength Light In Type 2 Idiopathic Macular Telangiectasia. Retina , 38 (Suppl. 1) S79-S88. 10.1097/IAE.0000000000001728. Green open access

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Abstract

PURPOSE: Macular telangiectasia Type 2 (MacTel) is a bilateral, progressive, potentially blinding retinal disease characterized by vascular and neurodegenerative signs, including an increased parafoveal reflectivity to blue light. Our aim was to investigate the relationship of this sign with other signs of macular telangiectasia Type 2 in multiple imaging modalities. METHODS: Participants were selected from the MacTel Type 2 study, based on a confirmed diagnosis and the availability of images. The extent of signs in blue-light reflectance, fluorescein angiographic, optical coherence tomographic, and single- and dual-wavelength autofluorescence images were analyzed. RESULTS: A well-defined abnormality of the perifovea is demonstrated by dual-wavelength autofluorescence and blue-light reflectance in early disease. The agreement in area size of the abnormalities in dual-wavelength autofluorescence and in blue-light reflectance images was excellent: for right eyes: ρ = 0.917 (P < 0.0001, 95% confidence interval 0.855-0.954, n = 46) and for left eyes: ρ = 0.952 (P < 0.0001, 95% confidence interval 0.916-0.973, n = 49). Other changes are less extensive initially and expand later to occupy that area and do not extend beyond it. CONCLUSION: Our findings indicate that abnormal metabolic handling of luteal pigment and physical changes giving rise to increased reflectance are widespread in the macula throughout the natural history of the disease, precede other changes, and are relevant to early diagnosis.

Type: Article
Title: Abnormal Retinal Reflectivity To Short-Wavelength Light In Type 2 Idiopathic Macular Telangiectasia
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/IAE.0000000000001728
Publisher version: http://dx.doi.org/10.1097/IAE.0000000000001728
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Adult, Aged, Aged, 80 and over, Disease Progression, Female, Fluorescein Angiography, Follow-Up Studies, Fundus Oculi, Humans, Light, Macula Lutea, Male, Middle Aged, Photic Stimulation, Prospective Studies, Retinal Vessels, Telangiectasia, Hereditary Hemorrhagic, Tomography, Optical Coherence
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1563002
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