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Quantifying Retinal Area in Ultra-Widefield Imaging Using a 3-Dimensional Printed Eye Model

Nicholson, L; Vazquez-Alfageme, C; Clemo, M; Luo, Y; Hykin, PG; Bainbridge, JW; Sivaprasad, S; (2018) Quantifying Retinal Area in Ultra-Widefield Imaging Using a 3-Dimensional Printed Eye Model. Ophthalmology Retina , 2 (1) pp. 65-71. 10.1016/j.oret.2017.03.011. Green open access

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Abstract

Purpose: To study the effects of different axial lengths on ultra-widefield imaging to determine the presence of distortion in images despite software correction and calculate an enlargement factor based on angular location. / Design: Experimental image analysis study. / Study Objects: Three 3-dimensional printed model eyes simulating eyes with axial lengths of 22, 24, and 26 mm. Each model has a grid of rings 9° apart centered at the posterior pole. / Methods: Single-center study performed at the National Institute for Health Research Moorfields Biomedical Research Centre (London, UK). Each model was imaged using Optos 200TX (Optos, Dunfermline, UK). Two images for each model eye that were corrected using V2 Vantage Pro software (Optos) were used for analysis and the average values obtained. Each image inter-ring area was measured using ImageJ to obtain a measured image area in pixel and square millimeters. This was compared with the true calculated object inter-ring area and an enlargement factor was determined. / Main Outcome Measures: Measured image inter-ring area in pixels and square millimeters. True calculated object inter-ring area in square millimeters. / Results: The enlargement factor of the rings gradually increases toward the periphery with factors of 1.4 at 45° and 1.9 at the equator. The axial lengths did not affect the enlargement factor of the rings imaged in 3 different model eyes (P = 0.9512). The anterior equator exhibits a significant distortion despite the software correction. / Conclusion: The enlargement factor depends on angular location and not axial length. The enlargement factors can be used in clinical practice to more accurately measure area in ultra-widefield imaging.

Type: Article
Title: Quantifying Retinal Area in Ultra-Widefield Imaging Using a 3-Dimensional Printed Eye Model
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.oret.2017.03.011
Publisher version: http://doi.org/10.1016/j.oret.2017.03.011
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1562684
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