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Theta burst magnetic stimulation over the pre-supplementary motor area improves motor inhibition

Obeso, I; Wilkinson, L; Teo, JT; Talelli, P; Rothwell, JC; Jahanshahi, M; (2017) Theta burst magnetic stimulation over the pre-supplementary motor area improves motor inhibition. Brain Stimulation , 10 (5) pp. 944-951. 10.1016/j.brs.2017.05.008. Green open access

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Abstract

BACKGROUND: Stopping an ongoing motor response or resolving conflict induced by conflicting stimuli are associated with activation of a right-lateralized network of inferior frontal gyrus (IFG), pre-supplementary motor area (pre-SMA) and subthalamic nucleus (STN). However, the roles of the right IFG and pre-SMA in stopping a movement and in conflict resolution remain unclear. We used continuous theta burst stimulation (cTBS) to examine the involvement of the right IFG and pre-SMA in inhibition and conflict resolution using the conditional stop signal task. METHODS: We measured stop signal reaction time (SSRT, measure of reactive inhibition), response delay effect (RDE, measure of proactive action restraint) and conflict induced slowing (CIS, measure of conflict resolution). RESULTS: Stimulation over the pre-SMA resulted in significantly shorter SSRTs (improved inhibition) compared to sham cTBS. This effect was not observed for CIS, RDE, or any other measures. cTBS over the right IFG had no effect on SSRT, CIS, RDE or on any other measure. CONCLUSIONS: The improvement of SSRT with cTBS over the pre-SMA suggests its critical contribution to stopping ongoing movements.

Type: Article
Title: Theta burst magnetic stimulation over the pre-supplementary motor area improves motor inhibition
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.brs.2017.05.008
Publisher version: https://doi.org/10.1016/j.brs.2017.05.008
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cognitive control, Conflict resolution, Pre-SMA, Response inhibition, Theta burst stimulation
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/1562227
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