UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Active dendritic integration as a mechanism for robust and precise grid cell firing

Schmidt-Hieber, C; Toleikyte, G; Aitchison, L; Roth, A; Clark, BA; Branco, T; Häusser, M; (2017) Active dendritic integration as a mechanism for robust and precise grid cell firing. Nature Neuroscience , 20 (8) pp. 1114-1121. 10.1038/nn.4582. Green open access

[thumbnail of Schmidt-Hieber2017.pdf]
Preview
Text
Schmidt-Hieber2017.pdf - Accepted version

Download (1MB) | Preview

Abstract

Understanding how active dendrites are exploited for behaviorally relevant computations is a fundamental challenge in neuroscience. Grid cells in medial entorhinal cortex are an attractive model system for addressing this question, as the computation they perform is clear: they convert synaptic inputs into spatially modulated, periodic firing. Whether active dendrites contribute to the generation of the dual temporal and rate codes characteristic of grid cell output is unknown. We show that dendrites of medial entorhinal cortex neurons are highly excitable and exhibit a supralinear input-output function in vitro, while in vivo recordings reveal membrane potential signatures consistent with recruitment of active dendritic conductances. By incorporating these nonlinear dynamics into grid cell models, we show that they can sharpen the precision of the temporal code and enhance the robustness of the rate code, thereby supporting a stable, accurate representation of space under varying environmental conditions. Our results suggest that active dendrites may therefore constitute a key cellular mechanism for ensuring reliable spatial navigation.

Type: Article
Title: Active dendritic integration as a mechanism for robust and precise grid cell firing
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nn.4582
Publisher version: http://dx.doi.org/10.1038/nn.4582
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Biophysical models, Dendritic excitability
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/1561374
Downloads since deposit
85Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item