Meidahl, AC;
Tinkhauser, G;
Herz, DM;
Cagnan, H;
Debarros, J;
Brown, P;
(2017)
Adaptive Deep Brain Stimulation for Movement Disorders: The Long Road to Clinical Therapy.
Movement Disorders
, 32
(6)
pp. 810-819.
10.1002/mds.27022.
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Abstract
Continuous high-frequency DBS is an established treatment for essential tremor and Parkinson's disease. Current developments focus on trying to widen the therapeutic window of DBS. Adaptive DBS (aDBS), where stimulation is dynamically controlled by feedback from biomarkers of pathological brain circuit activity, is one such development. Relevant biomarkers may be central, such as local field potential activity, or peripheral, such as inertial tremor data. Moreover, stimulation may be directed by the amplitude or the phase (timing) of the biomarker signal. In this review, we evaluate existing aDBS studies as proof-of-principle, discuss their limitations, most of which stem from their acute nature, and propose what is needed to take aDBS into a chronic setting. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society
| Type: | Article |
|---|---|
| Title: | Adaptive Deep Brain Stimulation for Movement Disorders: The Long Road to Clinical Therapy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mds.27022 |
| Publisher version: | http://dx.doi.org/10.1002/mds.27022 |
| Language: | English |
| Additional information: | © 2017 International Parkinson and Movement Disorder Society This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Deep brain stimulation, Parkinson's disease, brain-computer interface, essential tremor, closed-loop, PARKINSONS-DISEASE, SUBTHALAMIC NUCLEUS, ESSENTIAL TREMOR, SEGMENTAL DYSTONIA, COORDINATED RESET, GLOBUS-PALLIDUS, FOLLOW-UP, BETA, BRADYKINESIA, MODULATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1561349 |
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