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The promise of organ and tissue preservation to transform medicine

Giwa, S; Lewis, JK; Alvarez, L; Langer, R; Roth, AE; Church, GM; Markmann, JF; ... Toner, M; + view all (2017) The promise of organ and tissue preservation to transform medicine. Nature Biotechnology , 35 (6) pp. 530-542. 10.1038/nbt.3889. Green open access

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Abstract

The ability to replace organs and tissues on demand could save or improve millions of lives each year globally and create public health benefits on par with curing cancer. Unmet needs for organ and tissue preservation place enormous logistical limitations on transplantation, regenerative medicine, drug discovery, and a variety of rapidly advancing areas spanning biomedicine. A growing coalition of researchers, clinicians, advocacy organizations, academic institutions, and other stakeholders has assembled to address the unmet need for preservation advances, outlining remaining challenges and identifying areas of underinvestment and untapped opportunities. Meanwhile, recent discoveries provide proofs of principle for breakthroughs in a family of research areas surrounding biopreservation. These developments indicate that a new paradigm, integrating multiple existing preservation approaches and new technologies that have flourished in the past 10 years, could transform preservation research. Capitalizing on these opportunities will require engagement across many research areas and stakeholder groups. A coordinated effort is needed to expedite preservation advances that can transform several areas of medicine and medical science.

Type: Article
Title: The promise of organ and tissue preservation to transform medicine
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nbt.3889
Publisher version: http://dx.doi.org/10.1038/nbt.3889
Language: English
Additional information: © 2017 Nature America, Inc., part of Springer Nature. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Biotechnology & Applied Microbiology, PRIMARY GRAFT DYSFUNCTION, VIVO LUNG PERFUSION, HEMATOPOIETIC-CELL TRANSPLANTATION, DONOR KIDNEY-TRANSPLANTATION, METABOLIC-RATE DEPRESSION, LIVER-DISEASE SCORES, MACHINE PERFUSION, FERTILITY PRESERVATION, UNITED-STATES, CARDIAC DEATH
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/1561224
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