Lees, AJ;
Ferreira, J;
Rascol, O;
Reichmann, H;
Stocchi, F;
Tolosa, E;
Poewe, W;
(2017)
Opicapone for the management of end-of-dose motor fluctuations in patients with Parkinson's disease treated with L-DOPA.
Expert Review of Neurotherapeutics
, 17
(7)
pp. 649-659.
10.1080/14737175.2017.1336086.
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Abstract
INTRODUCTION: Opicapone is a third generation, highly potent and effective catechol O‑methyltransferase (COMT) inhibitor that optimizes the pharmacokinetics and bioavailability of L-DOPA therapy. AREAS COVERED: In this review, the authors describe the preclinical and clinical development of opicapone. In PD patients with motor fluctuations, once daily opicapone administration was well-tolerated and consistently reduced OFF-time and increased ON-time without increasing the frequency of troublesome dyskinesia, and these benefits were maintained over at least a year of continued open-label therapy. EXPERT COMMENTARY: With its convenient once-daily regimen, adjunct opicapone should be considered as an effective option for use in L-DOPA treated PD patients experiencing motor fluctuations.
| Type: | Article |
|---|---|
| Title: | Opicapone for the management of end-of-dose motor fluctuations in patients with Parkinson's disease treated with L-DOPA |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/14737175.2017.1336086 |
| Publisher version: | http://doi.org/10.1080/14737175.2017.1336086 |
| Language: | English |
| Additional information: | © 2017 Informa UK Limited, trading as Taylor & Francis Group. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | COMT inhibition, L-DOPA, Opicapone, Parkinson’s disease, motor fluctuations, wearing-off |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1561137 |
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