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Evolutionary Origins of Two-Barrel RNA Polymerases and Site-Specific Transcription Initiation

Fouqueau, T; Blombach, F; Werner, F; (2017) Evolutionary Origins of Two-Barrel RNA Polymerases and Site-Specific Transcription Initiation. Annual Review of Microbiology , 71 pp. 331-348. 10.1146/annurev-micro-091014-104145. Green open access

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Abstract

Evolutionary-related multisubunit RNA polymerases (RNAPs) carry out RNA synthesis in all domains life. Although their catalytic cores and fundamental mechanisms of transcription elongation are conserved, the initiation stage of the transcription cycle differs substantially in bacteria, archaea, and eukaryotes in terms of the requirements for accessory factors and details of the molecular mechanisms. This review focuses on recent insights into the evolution of the transcription apparatus with regard to (a) the surprisingly pervasive double-Ψ β-barrel active-site configuration among different nucleic acid polymerase families, (b) the origin and phylogenetic distribution of TBP, TFB, and TFE transcription factors, and (c) the functional relationship between transcription and translation initiation mechanisms in terms of transcription start site selection and RNA structure.

Type: Article
Title: Evolutionary Origins of Two-Barrel RNA Polymerases and Site-Specific Transcription Initiation
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1146/annurev-micro-091014-104145
Publisher version: https://doi.org/10.1146/annurev-micro-091014-10414...
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: multisubunit RNA polymerases, evolution, LUCA, translation initiation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1561085
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