Charlton, J;
Irtan, S;
Bergeron, C;
Pritchard-Jones, K;
(2017)
Bilateral Wilms tumour: a review of clinical and molecular features.
Expert Reviews in Molecular Medicine
, 19
, Article e8. 10.1017/erm.2017.8.
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Abstract
Wilms tumour (WT) is the most common paediatric kidney cancer and affects approximately one in 10 000 children. The tumour is associated with undifferentiated embryonic lesions called nephrogenic rests (NRs) or, when diffuse, nephroblastomatosis. WT or NRs can occur in both kidneys, termed bilateral disease, found in only 5–8% of cases. Management of bilateral WT presents a major clinical challenge in terms of maximising survival, preserving renal function and understanding underlying genetic risk. In this review, we compile clinical data from 545 published cases of bilateral WT and discuss recent progress in understanding the molecular basis of bilateral WT and its associated precursor NRs in the context of the latest radiological, surgical and epidemiological features.
| Type: | Article |
|---|---|
| Title: | Bilateral Wilms tumour: a review of clinical and molecular features |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1017/erm.2017.8 |
| Publisher version: | http://doi.org/10.1017/erm.2017.8 |
| Language: | English |
| Additional information: | © Cambridge University Press 2017. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Medicine, Research & Experimental, Research & Experimental Medicine, NEPHRON-SPARING SURGERY, SINGLE-CENTER EXPERIENCE, APPARENT DIFFUSION-COEFFICIENT, MOSAIC VARIEGATED ANEUPLOIDY, BECKWITH-WIEDEMANN-SYNDROME, CANCER-STUDY-GROUP, OF-THE-LITERATURE, ROUND-CELL TUMOR, BETA-CATENIN, IMAGING CHARACTERISTICS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1560517 |
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