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Hormone replacement treatment choices in complete androgen insensitivity syndrome: an audit of an adult clinic

Ko, JKY; King, TFJ; Williams, L; Creighton, SM; Conway, GS; (2017) Hormone replacement treatment choices in complete androgen insensitivity syndrome: an audit of an adult clinic. Endocrine Connections , 6 (6) pp. 375-379. 10.1530/EC-17-0083. Green open access

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Abstract

OBJECTIVE: To review the treatment choices of women with complete androgen insensitivity syndrome (CAIS) at a single tertiary centre. DESIGN: Retrospective review. PATIENTS: Women with CAIS identified from our database. RESULTS: The study group comprised 141 women with CAIS. Eleven percent (16/141) of women had gonads in situ, 3 of whom were under workup for gonadectomy. The age of gonadectomy in the remainder 125 women was 17 (0.1-53) years. The most common form of HRT was oral oestrogen or transdermal oestrogen in 80% (113/141). 13/141 (9%) women used vaginal oestrogens alone or together with other forms of HRT. Testosterone preparations had been used by 17% (24/141) of women and were currently used in 10% (14/141). Of those who had used testosterone, 42% (10/24) had chosen not to continue after a therapeutic trial. CONCLUSIONS: In a clinic offering individualised multidisciplinary care for women with CAIS, we found that the majority of women chose oestrogen-based treatment while a significant minority used testosterone.

Type: Article
Title: Hormone replacement treatment choices in complete androgen insensitivity syndrome: an audit of an adult clinic
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1530/EC-17-0083
Publisher version: http://doi.org/10.1530/EC-17-0083
Language: English
Additional information: © 2017 The authors. Published by Bioscientifica Ltd. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Keywords: Complete androgen insensitivity syndrome, hormone replacement therapy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
URI: https://discovery.ucl.ac.uk/id/eprint/1559686
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