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A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials

Dashnyam, K; El-Fiqi, A; Buitrago, JO; Perez, RA; Knowles, JC; Kim, H-W; (2017) A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials. Journal of Tissue Engineering , 8 pp. 1-13. 10.1177/2041731417707339. Green open access

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Abstract

Angiogenesis is considered an important issue in the development of biomaterials for the successful regeneration of tissues including bone. While growth factors are commonly used with biomaterials to promote angiogenesis, some ions released from biomaterials can also contribute to angiogenic events. Many silica-based biomaterials have been widely used for the repair and regeneration of tissues, mainly hard tissues such as bone and tooth structure. They have shown excellent performance in bone formation by stimulating angiogenesis. The release of silicate and others (Co and Cu ions) has therefore been implicated to play critical roles in the angiogenesis process. In this short review, we highlight the in vitro and in vivo findings of angiogenesis (and the related bone formation) stimulated by the various types of silicon-containing biomaterials where silicate ions released might play essential roles. We discuss further the possible molecular mechanisms underlying in the ion-induced angiogenic events.

Type: Article
Title: A mini review focused on the proangiogenic role of silicate ions released from silicon-containing biomaterials
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/2041731417707339
Publisher version: http://doi.org/10.1177/2041731417707339
Language: English
Additional information: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Keywords: Angiogenesis, bone stimulation, silicate ions, silicon-containing biomaterials
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1559156
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