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Peripheral Hypoarousal but Not Preparation-Vigilance Impairment Endures in ADHD Remission

James, S-N; Cheung, CHM; Rommel, A-S; McLoughlin, G; Brandeis, D; Banaschewski, T; Asherson, P; (2017) Peripheral Hypoarousal but Not Preparation-Vigilance Impairment Endures in ADHD Remission. Journal of Attention Disorders 10.1177/1087054717698813. (In press). Green open access

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Abstract

OBJECTIVE: This study investigates whether impairments associated with persistent ADHD-impaired attention allocation (P3 amplitude), peripheral hypoarousal (skin conductance level [SCL]), and adjustment in preparatory state (contingent negative variation [CNV])-reflect enduring deficits unrelated to ADHD outcome or are markers of ADHD remission. METHOD: Young people with childhood ADHD (73 persisters and 18 remitters) and 144 controls were compared on neurophysiological measures during two conditions (baseline and fast-incentive) of a four-choice reaction time task. RESULTS: ADHD remitters differed from persisters, and were indistinguishable from controls, on baseline P3 amplitude and fast-incentive CNV amplitude ( p ≤ .05). ADHD remitters differed from controls ( p ≤ .01), and were indistinguishable from persisters ( p > .05), on baseline SCL. CONCLUSION: Preparation-vigilance measures were markers of ADHD remission, confirming previous findings with other measures. Yet, SCL-measured peripheral hypoarousal emerges as an enduring deficit unrelated to ADHD improvement. Future studies should explore potential compensatory mechanisms that enable efficient preparation-vigilance processes in ADHD remitters.

Type: Article
Title: Peripheral Hypoarousal but Not Preparation-Vigilance Impairment Endures in ADHD Remission
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/1087054717698813
Publisher version: http://doi.org/10.1177/1087054717698813
Language: English
Additional information: Copyright © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Keywords: ADHD, EEG, adolescents, arousal, remission
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing
URI: https://discovery.ucl.ac.uk/id/eprint/1559062
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