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Detecting colorectal cancer using electrical impedance spectroscopy: an ex vivo feasibility study

Pathiraja, A; Ziprin, P; Shiraz, A; Mirnezami, R; Tizzard, A; Brown, B; Demosthenous, A; (2017) Detecting colorectal cancer using electrical impedance spectroscopy: an ex vivo feasibility study. Physiological Measurement , 38 (6) pp. 1278-1288. 10.1088/1361-6579/aa68ce. Green open access

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Abstract

OBJECTIVE: Colorectal cancer is the fourth most common cancer worldwide, with a lifetime risk of around 20%. Current techniques do not allow clinicians to objectively assess tissue abnormality during endoscopy and perioperatively. A method capable of objectively assessing samples in real time and which can be included in minimally invasive diagnostic and management strategies would be highly transformative. Electrical impedance spectroscopy (EIS) may provide such a solution. This paper presents a feasibility study on using EIS in assessing colorectal tissue. APPROACH: We performed tetrapolar EIS using ZedScan on excised human colorectal tumour tissue and the matched normal colonic mucosa in 22 freshly resected specimens following elective surgery for colorectal cancer. Histopathological examination was used to confirm the final diagnosis. Statistical significance was assessed using the Wilcoxon signed rank test. MAIN RESULTS: Tetrapolar EIS could discriminate cancer with statistically significant results when applying frequencies between 305 Hz and 625 kHz (p  <  0.05). 300 Ω was set as the transfer impedance threshold to detect cancer. Thus, the area under the corresponding receiver operating characteristic curve for this threshold was 0.7105. SIGNIFICANCE: This feasibility study demonstrates that impedance spectra changes in colorectal cancer tissue are detectable and may be statistically significant, suggesting that EIS has the potential to be the core technology in a novel non-invasive point of care test for detecting colorectal cancer. These results warrant further development by increasing the size of the study with a device specifically designed for colorectal cancer.

Type: Article
Title: Detecting colorectal cancer using electrical impedance spectroscopy: an ex vivo feasibility study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1088/1361-6579/aa68ce
Publisher version: http://doi.org/10.1088/1361-6579/aa68ce
Language: English
Additional information: © 2017 Institute of Physics and Engineering in Medicine. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Technology, Biophysics, Engineering, Biomedical, Physiology, Engineering, cancer, colorectal, diagnosis, electrical impedance spectroscopy (EIS), real-time, CERVICAL INTRAEPITHELIAL NEOPLASIA, DIELECTRIC-PROPERTIES, RECTAL-CANCER, REAL-TIME, TISSUE, RESECTION, SURGERY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Electronic and Electrical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1559033
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