UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Placenta-directed gene therapy for fetal growth restriction

Krishnan, T; David, AL; (2017) Placenta-directed gene therapy for fetal growth restriction. Seminars in Fetal and Neonatal Medicine , 22 (6) pp. 415-422. 10.1016/j.siny.2017.04.005. Green open access

[img]
Preview
Text
David-A_placenta-directed gene therapy_.pdf - Accepted version

Download (289kB) | Preview
[img]
Preview
Text
David-A_placenta_gene therapy_Table 1.pdf - Accepted version

Download (189kB) | Preview
[img]
Preview
Text
David-A_placenta_gene therapy_Table 2.pdf - Accepted version

Download (239kB) | Preview
[img]
Preview
Image
David-A_placenta_gene therapy_Figure 1.tiff - Accepted version

Download (1MB) | Preview

Abstract

Fetal growth restriction (FGR) is a serious pregnancy complication affecting ∼8% of all pregnancies. There is no treatment to increase fetal growth in the uterus. Gene therapy presents a promising treatment strategy for FGR, with the use of adenoviral vectors encoding for proteins such as vascular endothelial growth factor (VEGF) and insulin-like growth factor demonstrating improvements in fetal growth, placental function, and neonatal outcome in preclinical studies. Safety assessments suggest no adverse risk to the mother or fetus for VEGF maternal gene therapy; a clinical trial is in development. This review assesses research into placenta-directed gene therapy for FGR, investigating the use of transgenes and vectors, their route of administration in obstetrics, and the steps that will be needed to take this treatment modality into the clinic.

Type: Article
Title: Placenta-directed gene therapy for fetal growth restriction
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.siny.2017.04.005
Publisher version: https://doi.org/10.1016/j.siny.2017.04.005
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Fetal growth restriction, Gene therapy, Insulin-like growth factor, Placenta, Transduction, Vascular endothelial growth factor
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1558633
Downloads since deposit
248Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item