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Investigations of Carotid Stenosis to Identify Vulnerable Atherosclerotic Plaque and Determine Individual Stroke Risk

Liem, MI; Kennedy, F; Bonati, LH; van der Lugt, A; Coolen, BF; Nederveen, AJ; Jager, HR; ... Nederkoorn, PJ; + view all (2017) Investigations of Carotid Stenosis to Identify Vulnerable Atherosclerotic Plaque and Determine Individual Stroke Risk. Circulation Journal , 81 (9) pp. 1246-1253. 10.1253/circj.CJ-16-1284. Green open access

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Abstract

Selection of patients with atherosclerotic carotid stenosis for revascularization is mainly based on the degree of luminal narrowing of the carotid artery. However, identification of other features of plaque apart from the degree of stenosis could enable better selection for intervention if they are also associated with the occurrence of stroke. Before these risk factors can possibly play a role in treatment decisions, their prognostic value needs to be proven. The purpose of this narrative review is to summarize current knowledge regarding the risk factors for stroke in patients with carotid stenosis, how they can be determined, and to what extent they predict stroke, based on recent literature. References for this review were identified by searches of PubMed between 1995 and October, 2016 and references from relevant articles. For each topic in this review different relevant search terms were used. The main search terms were ‘carotid stenosis’, ‘atherosclerosis’, ‘stroke risk’, and ‘vulnerable plaque’. Language was restricted to English. The final reference list was generated on the basis of relevance to the topics covered in this review.

Type: Article
Title: Investigations of Carotid Stenosis to Identify Vulnerable Atherosclerotic Plaque and Determine Individual Stroke Risk
Open access status: An open access version is available from UCL Discovery
DOI: 10.1253/circj.CJ-16-1284
Publisher version: https://doi.org/10.1253/circj.CJ-16-1284
Language: English
Additional information: © 2017 The Japanese Circulation Society. This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Cardiovascular System & Cardiology, Carotid Stenosis, Ischemic Stroke, Plaque Imaging, Vulnerable Plaque, Transient Ischemic Attack, Artery Stenosis, Asymptomatic Embolization, 3-Dimensional Ultrasound, Computed-Tomography, Cryptogenic Stroke, Predicts Stroke, MRI, Metaanalysis, Endarterectomy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
URI: https://discovery.ucl.ac.uk/id/eprint/1557784
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