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A comprehensive guide to pilus biogenesis in Gram-negative bacteria

Hospenthal, MK; Costa, TRD; Waksman, G; (2017) A comprehensive guide to pilus biogenesis in Gram-negative bacteria. Nature Reviews Microbiology , 15 (6) pp. 365-379. 10.1038/nrmicro.2017.40. Green open access

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Abstract

Pili are crucial virulence factors for many Gram-negative pathogens. These surface structures provide bacteria with a link to their external environments by enabling them to interact with, and attach to, host cells, other surfaces or each other, or by providing a conduit for secretion. Recent high-resolution structures of pilus filaments and the machineries that produce them, namely chaperone-usher pili, type IV pili, conjugative type IV secretion pili and type V pili, are beginning to explain some of the intriguing biological properties that pili exhibit, such as the ability of chaperone-usher pili and type IV pili to stretch in response to external forces. By contrast, conjugative pili provide a conduit for the exchange of genetic information, and recent high-resolution structures have revealed an integral association between the pilin subunit and a phospholipid molecule, which may facilitate DNA transport. In addition, progress in the area of cryo-electron tomography has provided a glimpse of the overall architecture of the type IV pilus machinery. In this Review, we examine recent advances in our structural understanding of various Gram-negative pilus systems and discuss their functional implications.

Type: Article
Title: A comprehensive guide to pilus biogenesis in Gram-negative bacteria
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nrmicro.2017.40
Publisher version: http://doi.org/10.1038/nrmicro.2017.40
Language: English
Additional information: © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Bacterial Adhesion, Conjugation, Genetic, Fimbriae Proteins, Fimbriae, Bacterial, Gram-Negative Bacteria, Virulence Factors
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1557577
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