Engel, TA;
Steinmetz, NA;
Gieselmann, MA;
Thiele, A;
Moore, T;
Boahen, K;
(2016)
Selective modulation of cortical state during spatial attention.
Science
, 354
(6316)
pp. 1140-1144.
10.1126/science.aag1420.
Preview |
Text
Engel_Selective_modulation_cortical.pdf - Accepted Version Download (5MB) | Preview |
Abstract
Neocortical activity is permeated with endogenously generated fluctuations, but how these dynamics affect goal-directed behavior remains a mystery. We found that ensemble neural activity in primate visual cortex spontaneously fluctuated between phases of vigorous (On) and faint (Off) spiking synchronously across cortical layers. These On-Off dynamics, reflecting global changes in cortical state, were also modulated at a local scale during selective attention. Moreover, the momentary phase of local ensemble activity predicted behavioral performance. Our results show that cortical state is controlled locally within a cortical map according to cognitive demands and reveal the impact of these local changes in cortical state on goal-directed behavior.
Type: | Article |
---|---|
Title: | Selective modulation of cortical state during spatial attention |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1126/science.aag1420 |
Publisher version: | https://doi.org/10.1126/science.aag1420 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
URI: | https://discovery.ucl.ac.uk/id/eprint/1557431 |
Archive Staff Only
View Item |