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Selective modulation of cortical state during spatial attention

Engel, TA; Steinmetz, NA; Gieselmann, MA; Thiele, A; Moore, T; Boahen, K; (2016) Selective modulation of cortical state during spatial attention. Science , 354 (6316) pp. 1140-1144. 10.1126/science.aag1420. Green open access

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Abstract

Neocortical activity is permeated with endogenously generated fluctuations, but how these dynamics affect goal-directed behavior remains a mystery. We found that ensemble neural activity in primate visual cortex spontaneously fluctuated between phases of vigorous (On) and faint (Off) spiking synchronously across cortical layers. These On-Off dynamics, reflecting global changes in cortical state, were also modulated at a local scale during selective attention. Moreover, the momentary phase of local ensemble activity predicted behavioral performance. Our results show that cortical state is controlled locally within a cortical map according to cognitive demands and reveal the impact of these local changes in cortical state on goal-directed behavior.

Type: Article
Title: Selective modulation of cortical state during spatial attention
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/science.aag1420
Publisher version: https://doi.org/10.1126/science.aag1420
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1557431
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