Mons, U;
Mueezzinler, A;
Schoettker, B;
Dieffenbach, AK;
Butterbach, K;
Schick, M;
Peasey, A;
... Brenner, H; + view all
(2017)
Leukocyte Telomere Length and All-Cause, Cardiovascular Disease, and Cancer Mortality: Results From Individual-Participant-Data Meta-Analysis of 2 Large Prospective Cohort Studies.
American Journal of Epidemiology
, 185
(12)
pp. 1317-1326.
10.1093/aje/kww210.
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Abstract
We studied the associations of leukocyte telomere length (LTL) with all-cause, cardiovascular disease, and cancer mortality in 12,199 adults participating in 2 population-based prospective cohort studies from Europe (ESTHER) and the United States (Nurses’ Health Study). Blood samples were collected in 1989–1990 (Nurses’ Health Study) and 2000–2002 (ESTHER). LTL was measured by quantitative polymerase chain reaction. We calculated z scores for LTL to standardize LTL measurements across the cohorts. Cox proportional hazards regression models were used to calculate relative mortality according to continuous levels and quintiles of LTL z scores. The hazard ratios obtained from each cohort were subsequently pooled by meta-analysis. Overall, 2,882 deaths were recorded during follow-up (Nurses’ Health Study, 1989–2010; ESTHER, 2000–2015). LTL was inversely associated with age in both cohorts. After adjustment for age, a significant inverse trend of LTL with all-cause mortality was observed in both cohorts. In random-effects meta-analysis, age-adjusted hazard ratios for the shortest LTL quintile compared with the longest were 1.23 (95% confidence interval (CI): 1.04, 1.46) for all-cause mortality, 1.29 (95% CI: 0.83, 2.00) for cardiovascular mortality, and 1.10 (95% CI: 0.88, 1.37) for cancer mortality. In this study population with an age range of 43–75 years, we corroborated previous evidence suggesting that LTL predicts all-cause mortality beyond its association with age.
| Type: | Article |
|---|---|
| Title: | Leukocyte Telomere Length and All-Cause, Cardiovascular Disease, and Cancer Mortality: Results From Individual-Participant-Data Meta-Analysis of 2 Large Prospective Cohort Studies |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/aje/kww210 |
| Publisher version: | http://doi.org/10.1093/aje/kww210 |
| Language: | English |
| Additional information: | © The Author 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Public, Environmental & Occupational Health, aging, all-cause mortality, cancer mortality, cardiovascular disease mortality, cohort studies, leukocytes, telomere length, PERIPHERAL-BLOOD LEUKOCYTES, MYOCARDIAL-INFARCTION, QUANTITATIVE PCR, INCIDENT CANCER, HEART-DISEASE, RISK, HEALTH, ASSOCIATION, POPULATION, BIOMARKER |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1557415 |
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