Hayes, W;
(2017)
Stop adding insult to injury—identifying and managing risk factors for the progression of acute kidney injury in children.
Pediatric Nephrology
10.1007/s00467-017-3598-3.
(In press).
Preview |
Text
art%3A10.1007%2Fs00467-017-3598-3.pdf - Published Version Download (566kB) | Preview |
Abstract
Acute kidney injury (AKI) is common in children admitted to hospital. Whilst some recover normal kidney function following an acute kidney insult, a significant proportion experience long-term sequelae. The aim of this review is to summarize current understanding of the processes that can lead to sequelae following AKI. Kidney injury, repair, recovery and progression are described. Risk factors for progression are outlined, and potential strategies to stratify the risk of progression in children with AKI are discussed. Clinical management priorities to minimize sequelae are suggested. Looking ahead, novel therapeutic targets are discussed with the potential to accelerate adaptive repair and ameliorate the progression and sequelae of AKI in the future.
| Type: | Article |
|---|---|
| Title: | Stop adding insult to injury—identifying and managing risk factors for the progression of acute kidney injury in children |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00467-017-3598-3 |
| Publisher version: | http://dx.doi.org/10.1007/s00467-017-3598-3 |
| Language: | English |
| Additional information: | © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| Keywords: | AKI; Children; Progression; CKD; Hypertension |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1557308 |
Archive Staff Only
 |
View Item |
