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Medial Entorhinal Cortex Selectively Supports Temporal Coding by Hippocampal Neurons

Robinson, NTM; Priestley, JB; Rueckemann, JW; Garcia, AD; Smeglin, VA; Marino, FA; Eichenbaum, H; (2017) Medial Entorhinal Cortex Selectively Supports Temporal Coding by Hippocampal Neurons. Neuron , 94 (3) 677-688.e6. 10.1016/j.neuron.2017.04.003. Green open access

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Abstract

Recent studies have shown that hippocampal “time cells” code for sequential moments in temporally organized experiences. However, it is currently unknown whether these temporal firing patterns critically rely on upstream cortical input. Here we employ an optogenetic approach to explore the effect of large-scale inactivation of the medial entorhinal cortex on temporal, as well as spatial and object, coding by hippocampal CA1 neurons. Medial entorhinal inactivation produced a specific deficit in temporal coding in CA1 and resulted in significant impairment in memory across a temporal delay. In striking contrast, spatial and object coding remained intact. Further, we extended the scope of hippocampal phase precession to include object information relevant to memory and behavior. Overall, our work demonstrates that medial entorhinal activity plays an especially important role for CA1 in temporal coding and memory across time.

Type: Article
Title: Medial Entorhinal Cortex Selectively Supports Temporal Coding by Hippocampal Neurons
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2017.04.003
Publisher version: https://doi.org/10.1016/j.neuron.2017.04.003
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, Human Spatial Navigation, Theta Sequences, Association Memory, Phase Precession, Single Neurons, Grid Cells, Place, Time, Rat, CA1
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/1556764
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