Arasanz, H;
Gato-Canas, M;
Zuazo, M;
Ibanez-Vea, M;
Breckpot, K;
Kochan, G;
Escors, D;
(2017)
PD1 signal transduction pathways in T cells.
Oncotarget
, 8
(31)
pp. 51936-51945.
10.18632/oncotarget.17232.
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Abstract
The use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating high efficacies and low toxicities. Despite all the recent advances, very little is yet known on the molecular intracellular signaling pathways regulated by either PD-L1 or PD1. Here we review the current knowledge on PD1-dependent intracellular signaling pathways, and the consequences of disrupting PD1 signal transduction.
| Type: | Article |
|---|---|
| Title: | PD1 signal transduction pathways in T cells |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.18632/oncotarget.17232 |
| Publisher version: | http://dx.doi.org/10.18632/oncotarget.17232 |
| Language: | English |
| Additional information: | © Arasanz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Oncology, Cell Biology, PD-L1, PDL1, PD1, B7-H1, cancer, RECEPTOR DOWN-MODULATION, PD-L1 CO-STIMULATION, CBL-B, UNTREATED MELANOMA, PROGRAMMED DEATH-1, EFFECTOR FUNCTION, ZETA-CHAIN, ACTIVATION, ANTIGEN, PROTEIN |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1556540 |
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