UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

ADP-Ribosyl Cyclases Regulate Early Development of the Sea Urchin

Ramakrishnan, L; Uhlinger, K; Dale, L; Hamdoun, A; Patel, S; (2016) ADP-Ribosyl Cyclases Regulate Early Development of the Sea Urchin. Messenger , 5 (1-2) pp. 100-106. 10.1166/msr.2016.1052. Green open access

[img]
Preview
Text
s11.pdf - Published version

Download (5MB) | Preview

Abstract

ADP-ribosyl cyclases are multifunctional enzymes involved in the metabolism of nucleotide derivatives necessary for Ca2+ signalling such as cADPR and NAADP. Although Ca2+ signalling is a critical regulator of early development, little is known of the role of ADP-ribosyl cyclases during embryogenesis. Here we analyze the expression, activity and function of ADP-ribosyl cyclases in the embryo of the sea urchin–a key organism for study of both Ca2+ signalling and embryonic development. ADP-ribosyl cyclase isoforms (SpARC1-4) showed unique changes in expression during early development. These changes were associated with an increase in the ratio of cADPR:NAADP production. Over-expression of SpARC4 (a preferential cyclase) disrupted gastrulation. Our data highlight the importance of ADP-ribosyl cyclases during embryogenesis.

Type: Article
Title: ADP-Ribosyl Cyclases Regulate Early Development of the Sea Urchin
Open access status: An open access version is available from UCL Discovery
DOI: 10.1166/msr.2016.1052
Publisher version: http://doi.org/10.1166/msr.2016.1052
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: ADP-RIBOSYL CYCLASE, CYCLIC ADP-RIBOSE, EARLY DEVELOPMENT, GASTRULATION, NAADP
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1556538
Downloads since deposit
61Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item