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Deviant Lysosomal Ca 2 + Signalling in Neurodegeneration. An Introduction

Patel, S; (2016) Deviant Lysosomal Ca 2 + Signalling in Neurodegeneration. An Introduction. Messenger , 5 (1-2) pp. 24-29. 10.1166/msr.2016.1053. Green open access

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Abstract

Lysosomes are key acidic Ca2+ stores. The principle Ca2+-permeable channels of the lysosome are TRP mucolipins (TRPMLs) and NAADP-regulated two-pore channels (TPCs). Recent studies, reviewed in this collection, have linked numerous neurodegenerative diseases to both gain and loss of function of TRPMLs/TPCs, as well as to defects in acidic Ca2+ store content. These diseases span rare lysosomal storage disorders such as Mucolipidosis Type IV and Niemann–Pick disease, type C, through to more common ones such as Alzheimer and Parkinson disease. Cellular phenotypes, underpinned by endo-lysosomal trafficking defects, are reversed by chemical or molecular targeting of TRPMLs and TPCs. Lysosomal ion channels therefore emerge as potential druggable targets in combatting neurodegeneration.

Type: Article
Title: Deviant Lysosomal Ca 2 + Signalling in Neurodegeneration. An Introduction
Open access status: An open access version is available from UCL Discovery
DOI: 10.1166/msr.2016.1053
Publisher version: http://doi.org/10.1016/j.atherosclerosis.2011.08.0...
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: ACIDIC CA2+ STORES, CA2+, LYSOSOMES, MCOLN1, NAADP, NEURODEGENERATION, PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE, TPCN1, TPCN2
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1556537
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