Arroyo, V;
Kamath, PS;
Moreau, R;
Jalan, R;
Gines, P;
Nevens, F;
Fernandez, J;
... Schnabl, B; + view all
(2016)
Acute-on-Chronic Liver Failure: Definition, Diagnosis, and Clinical Characteristics.
Seminars in Liver Disease
, 36
(2)
pp. 109-116.
10.1055/s-0036-1583202.
Preview |
Text
Jalan_Acute-on-Chronic Liver Failure Definition Diagnosis and Clinical Characteristics ACLF Sem Liver Dis draft 3 31Aug2017.pdf - Accepted Version Download (311kB) | Preview |
Abstract
Acute-on-chronic liver failure (ACLF) is a recently recognized syndrome in cirrhosis characterized by acute decompensation (AD), organ failure(s), and high short-term mortality. Organ failure(s) is defined by the Chronic Liver Failure-Sequential Organ Failure (CLIF-SOFA) score or by its simplified version Chronic Liver Failure-Organ Failure Assessment (CLIF-OF) score. They include six types of organ failure: liver, renal, coagulation, cerebral, respiratory, and circulatory. One third of patients hospitalized with AD present with ACLF at admission or develop ACLF during hospitalization. Acute-on-chronic liver failure frequently occurs in a closed relationship to a precipitating event. According to the number of organ failures, ACLF is graded into three stages: ACLF-1 = single renal failure or single nonrenal organ failure if associated with renal dysfunction and/or cerebral dysfunction; ACLF-2 = two organ failures; and ACLF-3 = three to six organ failures, with increasing 28-day mortality rate (from 23%–74%). Acute-on-chronic liver failure may develop at any phase during the clinical course of the disease. Patients without prior AD develop a severe form of ACLF.
Type: | Article |
---|---|
Title: | Acute-on-Chronic Liver Failure: Definition, Diagnosis, and Clinical Characteristics |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1055/s-0036-1583202 |
Publisher version: | http://dx.doi.org/10.1055/s-0036-1583202 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Decompensated cirrhosis, organ failure, acute-on-chronic liver failure, PERIPHERAL ARTERIAL VASODILATION, ASIAN-PACIFIC ASSOCIATION, ORGAN FAILURE, CONSENSUS RECOMMENDATIONS, HEPATORENAL-SYNDROME, SCORING SYSTEM, CLIF-SOFA, CIRRHOSIS, VALIDATION, MORTALITY |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth |
URI: | https://discovery.ucl.ac.uk/id/eprint/1555214 |
Archive Staff Only
View Item |