Barrington, C;
Finn, R;
Hadjur, S;
(2017)
Cohesin biology meets the loop extrusion model.
Chromosome Research
, 25
(1)
pp. 51-60.
10.1007/s10577-017-9550-3.
Preview |
Text
Hadjur_art%253A10.1007%252Fs10577-017-9550-3.pdf - Published Version Download (618kB) | Preview |
Abstract
Extensive research has revealed that cohesin acts as a topological device, trapping chromosomal DNA within a large tripartite ring. In so doing, cohesin contributes to the formation of compact and organized genomes. How exactly the cohesin subunits interact, how it opens, closes, and translocates on chromatin, and how it actually tethers DNA strands together are still being elucidated. A comprehensive understanding of these questions will shed light on how cohesin performs its many functions, including its recently proposed role as a chromatid loop extruder. Here, we discuss this possibility in light of our understanding of the molecular properties of cohesin complexes.
| Type: | Article |
|---|---|
| Title: | Cohesin biology meets the loop extrusion model |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s10577-017-9550-3 |
| Publisher version: | http://dx.doi.org/10.1007/s10577-017-9550-3 |
| Language: | English |
| Additional information: | © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Genetics & Heredity, Cohesin, Ctcf, Chromosomal Domain, Loop Extrusion, Sister-Chromatid Cohesion, Gene-Expression, Saccharomyces-Cerevisiae, Atpase Activity, Smc Proteins, Human-Cells, C-Terminus, Dna, Architecture, Chromosomes |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1553938 |
Archive Staff Only
 |
View Item |
