Schurich, A;
Raine, C;
Morris, V;
Ciurtin, C;
(2017)
The role of IL-12/23 in T cell-related chronic inflammation: implications of immunodeficiency and therapeutic blockade.
Rheumatology
, 57
(2)
pp. 246-254.
10.1093/rheumatology/kex186.
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Abstract
In this review we discuss the divergent role of two closely related cytokines, IL-12 and IL-23, in shaping immune responses. In light of current therapeutic developments using biologic agents to block these two pathways, a better understanding of the immunological function of these cytokines is pivotal.
| Type: | Article |
|---|---|
| Title: | The role of IL-12/23 in T cell-related chronic inflammation: implications of immunodeficiency and therapeutic blockade |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/rheumatology/kex186 |
| Publisher version: | http://doi.org/10.1093/rheumatology/kex186 |
| Language: | English |
| Additional information: | © The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | IL-12 related immunodeficiency, IL-12/23 blockade, briakinumab, psoriasis, psoriatic arthritis, ustekinumab |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1553548 |
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