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The role of IL-12/23 in T cell-related chronic inflammation: implications of immunodeficiency and therapeutic blockade

Schurich, A; Raine, C; Morris, V; Ciurtin, C; (2017) The role of IL-12/23 in T cell-related chronic inflammation: implications of immunodeficiency and therapeutic blockade. Rheumatology , 57 (2) pp. 246-254. 10.1093/rheumatology/kex186. Green open access

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Abstract

In this review we discuss the divergent role of two closely related cytokines, IL-12 and IL-23, in shaping immune responses. In light of current therapeutic developments using biologic agents to block these two pathways, a better understanding of the immunological function of these cytokines is pivotal.

Type: Article
Title: The role of IL-12/23 in T cell-related chronic inflammation: implications of immunodeficiency and therapeutic blockade
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/rheumatology/kex186
Publisher version: http://doi.org/10.1093/rheumatology/kex186
Language: English
Additional information: © The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: IL-12 related immunodeficiency, IL-12/23 blockade, briakinumab, psoriasis, psoriatic arthritis, ustekinumab
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1553548
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