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Mitochondrial cytochrome c oxidase: catalysis, coupling and controversies

Rich, PR; (2017) Mitochondrial cytochrome c oxidase: catalysis, coupling and controversies. Biochemical Society Transactions , 45 (3) pp. 813-829. 10.1042/BST20160139. Green open access

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Abstract

Mitochondrial cytochrome c oxidase is a member of a diverse superfamily of haem–copper oxidases. Its mechanism of oxygen reduction is reviewed in terms of the cycle of catalytic intermediates and their likely chemical structures. This reaction cycle is coupled to the translocation of protons across the inner mitochondrial membrane in which it is located. The likely mechanism by which this occurs, derived in significant part from studies of bacterial homologues, is presented. These mechanisms of catalysis and coupling, together with current alternative proposals of underlying mechanisms, are critically reviewed.

Type: Article
Title: Mitochondrial cytochrome c oxidase: catalysis, coupling and controversies
Open access status: An open access version is available from UCL Discovery
DOI: 10.1042/BST20160139
Publisher version: http://doi.org/10.1042/BST20160139
Language: English
Additional information: © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, COPPER RESPIRATORY OXIDASES, PROTON-TRANSFER PATHWAYS, ACTIVE-SITE TYROSINE, PARACOCCUS-DENITRIFICANS, RHODOBACTER-SPHAEROIDES, ELECTRON-TRANSFER, OXYGEN REDUCTION, FTIR SPECTROSCOPY, HYDROGEN-PEROXIDE, TERMINAL OXIDASES
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1553109
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