Maertens, K;
Burbidge, P;
Van Damme, P;
Goldblatt, D;
Leuridan, E;
(2017)
Pneumococcal Immune Response in Infants Whose Mothers Received Tdap Vaccination During Pregnancy.
Pediatric Infectious Disease Journal
, 36
(12)
pp. 1186-1192.
10.1097/INF.0000000000001601.
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Abstract
BACKGROUND: Maternal immunization with a tetanus, diphtheria and acellular pertussis (Tdap) vaccine may blunt infant pneumococcal immune responses after a primary series of vaccines. METHODS: As part of a prospective controlled cohort trial of Tdap (Boostrix®, GSK Biologicals) vaccination in pregnancy, infants born to vaccinated mothers and controls were immunized at 8 and 16 weeks and 12 months of age with 13-valent pneumococcal conjugate vaccine (Prevenar13®, Pfizer). Sera were tested for pneumococcal antibody concentrations against vaccine serotypes following primary and booster immunization. RESULTS: Geometric mean concentration (GMC) of antibodies to serotype 1, 3, 4, 5, 6A, 7F, 9V, 14 and 19A were significantly lower after 2 doses of Prevenar13® vaccine in the offspring of the mothers vaccinated in pregnancy. This blunting effect disappeared after a booster dose at the age of 12 months, except for serotype 1 and 4. Despite this blunting, the percentage of children achieving the threshold of protection of 0.35 µg/mL was comparable in the vaccine and the control group both after primary and booster vaccination with only a significant lower rate of seroprotection in the vaccine group for serotype 3 after primary vaccination. After booster vaccination, seroprotection rates increased further for serotypes 3, 5, 6B, 9V and 23F. CONCLUSIONS: The present results indicate a blunting effect post-primary vaccination for some serotypes resolving after booster vaccination. Seroprotection rates were comparable both after primary and booster vaccination, except for serotype 3 with a significant lower seroprotection rate in the vaccine group after primary vaccination.
| Type: | Article |
|---|---|
| Title: | Pneumococcal Immune Response in Infants Whose Mothers Received Tdap Vaccination During Pregnancy |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/INF.0000000000001601 |
| Publisher version: | http://dx.doi.org/10.1097/INF.0000000000001601 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Tdap, vaccination in pregnancy, infant pneumococcal immune response |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1552862 |
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