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Serum inflammatory markers and colorectal cancer risk and survival.

Ghuman, S; Van Hemelrijck, M; Garmo, H; Holmberg, L; Malmström, H; Lambe, M; Hammar, N; ... Wulaningsih, W; + view all (2017) Serum inflammatory markers and colorectal cancer risk and survival. Br J Cancer , 116 (10) pp. 1358-1365. 10.1038/bjc.2017.96. Green open access

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BACKGROUND: Inflammation has been linked with development of some cancers. We investigated systemic inflammation in relation to colorectal cancer incidence and subsequent survival using common serum inflammatory markersDesign:A cohort of men and women aged 20 years and older in greater Stockholm area with serum C-reactive protein (CRP) and albumin measured between 1986 and 1999 were included (n=325 599). A subset of these had baseline measurements of haptoglobin and leukocytes. Multivariable Cox regression was performed to assess risk of colorectal cancer by levels of inflammatory markers, adjusting for potential confounders. Analyses were stratified by circulating glucose, total cholesterol and triglycerides. Overall and CRC-specific death following diagnosis were assessed as secondary outcomes. RESULTS: A total of 4764 individuals were diagnosed with colorectal cancer. A positive association between haptoglobin and colorectal cancer incidence was found (hazard ratio (HR): 1.17; 95% CI: 1.06-1.28). A positive association was also observed with leukocytes (HR: 1.21; 95% CI: 1.03-1.42). No evidence of association was noted between CRP and colorectal cancer risk. Higher risks of all-cause death were seen with haptoglobin and leukocytes levels. Higher haptoglobin levels were linked with an increased risk of colorectal cancer death (HR: 1.19; 95% CI: 1.01-1.41). CONCLUSIONS: Prediagnostic systemic inflammation may impact colorectal cancer incidence and survival; therefore, prompting investigations linking inflammatory pathways preceding colorectal cancer with disease severity and progression.

Type: Article
Title: Serum inflammatory markers and colorectal cancer risk and survival.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/bjc.2017.96
Publisher version: http://dx.doi.org/10.1038/bjc.2017.96
Language: English
Additional information: This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License.
Keywords: Colorectal cancer; CRP; haptoglobin; leukocytes; albumin
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
URI: https://discovery.ucl.ac.uk/id/eprint/1552838
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