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Decellularized material as scaffolds for tissue engineering studies in long gap esophageal atresia

Lee, E; Milan, A; Urbani, L; De Coppi, P; Lowdell, MW; (2017) Decellularized material as scaffolds for tissue engineering studies in long gap esophageal atresia. Expert Opinion on Biological Therapy , 17 (5) pp. 573-584. 10.1080/14712598.2017.1308482. Green open access

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Abstract

INTRODUCTION: Esophageal atresia refers to an anomaly in foetal development in which the esophagus terminates in a blind end. Whilst surgical correction is achievable in most patients, when a long gap is present it still represents a major challenge associated with higher morbidity and mortality. In this context, tissue engineering could represent a successful alternative to restore oesophageal function and structure. Naturally derived biomaterials made of decellularized tissues retain native extracellular matrix architecture and composition, providing a suitable bed for the anchorage and growth of relevant cell types. AREAS COVERED: This review outlines the various strategies and challenges in esophageal tissue engineering, highlighting the evolution of ideas in the development of decellularized scaffolds for clinical use. It explores the interplay between clinical needs, ethical dilemmas, and manufacturing challenges in the development of a tissue engineered decellularized scaffold for oesophageal atresia. EXPERT OPINION: Current progress on oesophageal tissue engineering has enabled effective repair of patch defects, whilst the development of a full circumferential construct remains a challenge. Despite the different approaches available and the improvements achieved, a gold standard for fully functional tissue engineered oesophageal constructs has not been defined yet.

Type: Article
Title: Decellularized material as scaffolds for tissue engineering studies in long gap esophageal atresia
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/14712598.2017.1308482
Publisher version: http://doi.org/10.1080/14712598.2017.1308482
Language: English
Additional information: © 2017 Informa UK Limited, trading as Taylor & Francis Group. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Biotechnology & Applied Microbiology, Medicine, Research & Experimental, Research & Experimental Medicine, SMALL-INTESTINAL SUBMUCOSA, SILICONE COMPOSITE TUBE, EPITHELIAL-CELL SHEETS, SMOOTH-MUSCLE-CELLS, EXTRACELLULAR-MATRIX, ARTIFICIAL ESOPHAGUS, IN-VITRO, REGENERATIVE MEDICINE, CANINE MODEL, FOLLOW-UP
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1552828
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