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Molecular and Metabolic Imaging in Multiple Sclerosis

Moccia, M; Ciccarelli, O; (2017) Molecular and Metabolic Imaging in Multiple Sclerosis. Neuroimaging Clinics of North America , 27 (2) pp. 343-356. 10.1016/j.nic.2016.12.005. Green open access

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Abstract

* Molecular and metabolic imaging techniques assess dynamically and in vivo the pathogenetic mechanisms that lead to MS pathology and reflect the heterogeneity of pathologic abnormalities occurring in MS. *1 H-MR spectroscopy estimates brain levels of several metabolites, which reflect important biologic processes, such as mitochondrial function and/or neuronal integrity (N-acetyl-aspartate), and glial cell activation and proliferation (myo-inositol). * 23Na MR imaging estimates the total concentration of sodium within regions-of-interest in the brain. Increased total sodium concentration is thought to reflect axonal impaired energy metabolism and neurodegeneration. * PET permits the characterization of the biologic processes occurring at the cellular and molecular levels. The following radioligands are often used: 18F-fluoro-2’-deoxyglucose to investigate inflammation, translocator protein tracers to study microglia activation, amyloid tracers to study demyelination, and 11C-flumazenil to investigate neuronal damage. * Although technically challenging and expensive, the translation of these techniques to clinical trials and the clinical setting may allow stratification of patients for treatments.

Type: Article
Title: Molecular and Metabolic Imaging in Multiple Sclerosis
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.nic.2016.12.005
Publisher version: http://doi.org/10.1016/j.nic.2016.12.005
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Multiple sclerosis; MR imaging; Spectroscopy; PET; Molecular; Metabolic
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1552778
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