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Qualitative and quantitative HIV antibodies and viral reservoir size characterization in vertically infected children with virological suppression

Brice, J; Sylla, M; Sayon, S; Telly, F; Bocar-Fofana, D; Murphy, R; Lambert-Niclot, S; ... Maiga, AI; + view all (2016) Qualitative and quantitative HIV antibodies and viral reservoir size characterization in vertically infected children with virological suppression. Journal of Antimicrobial Chemotherapy , 72 (4) pp. 1147-1151. 10.1093/jac/dkw537. Green open access

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Abstract

Background: Absence of detectable viraemia after treatment cessation in some vertically HIV-infected (VHIV) children suggests that early initiation of HAART could lead to functional cure. Objectives: We described the factors associated with HIV antibody levels and the viral reservoir size in HAART-treated VHIV children. Methods: Study included 97 VHIV children with virological suppression, in Bamako, Mali. The anti-gp41 antibody activities and HIV serostatus were assessed. The viral reservoir size was measured by quantifying total cell-associated HIV DNA. Results: Among the children studied, the median total HIV DNA level was 445 copies/106 cells (IQR = 187–914) and the median anti-gp41 antibody activity was 0.29 OD (IQR = 0.18–0.75). Low activity of anti-gp41 antibodies was associated with a younger age of HAART initiation (P = 0.01). Overall, eight HIV-1 seroreversions were identified. Conclusions: Study identified potential candidates with low viral reservoir and low antibody levels or activities for future trials aiming to reduce HIV-1 reservoir to limit HAART duration.

Type: Article
Title: Qualitative and quantitative HIV antibodies and viral reservoir size characterization in vertically infected children with virological suppression
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/jac/dkw537
Publisher version: https://doi.org/10.1093/jac/dkw537
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, Microbiology, Pharmacology & Pharmacy, IMMUNODEFICIENCY-VIRUS TYPE-1, EARLY ANTIRETROVIRAL THERAPY, HIV-1-INFECTED CHILDREN, IMMUNE-RESPONSES, AGE, REPLICATION, TRIAL, DECAY
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1551219
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