Brice, J;
Sylla, M;
Sayon, S;
Telly, F;
Bocar-Fofana, D;
Murphy, R;
Lambert-Niclot, S;
... Maiga, AI; + view all
(2016)
Qualitative and quantitative HIV antibodies and viral reservoir size characterization in vertically infected children with virological suppression.
Journal of Antimicrobial Chemotherapy
, 72
(4)
pp. 1147-1151.
10.1093/jac/dkw537.
Preview |
Text
Derache_Qualitative and quantitative HIV antibodies and viral reservoir size characterization_.pdf - Accepted Version Download (618kB) | Preview |
Abstract
Background: Absence of detectable viraemia after treatment cessation in some vertically HIV-infected (VHIV) children suggests that early initiation of HAART could lead to functional cure. Objectives: We described the factors associated with HIV antibody levels and the viral reservoir size in HAART-treated VHIV children. Methods: Study included 97 VHIV children with virological suppression, in Bamako, Mali. The anti-gp41 antibody activities and HIV serostatus were assessed. The viral reservoir size was measured by quantifying total cell-associated HIV DNA. Results: Among the children studied, the median total HIV DNA level was 445 copies/106 cells (IQR = 187–914) and the median anti-gp41 antibody activity was 0.29 OD (IQR = 0.18–0.75). Low activity of anti-gp41 antibodies was associated with a younger age of HAART initiation (P = 0.01). Overall, eight HIV-1 seroreversions were identified. Conclusions: Study identified potential candidates with low viral reservoir and low antibody levels or activities for future trials aiming to reduce HIV-1 reservoir to limit HAART duration.
Type: | Article |
---|---|
Title: | Qualitative and quantitative HIV antibodies and viral reservoir size characterization in vertically infected children with virological suppression |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1093/jac/dkw537 |
Publisher version: | https://doi.org/10.1093/jac/dkw537 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, Microbiology, Pharmacology & Pharmacy, IMMUNODEFICIENCY-VIRUS TYPE-1, EARLY ANTIRETROVIRAL THERAPY, HIV-1-INFECTED CHILDREN, IMMUNE-RESPONSES, AGE, REPLICATION, TRIAL, DECAY |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences |
URI: | https://discovery.ucl.ac.uk/id/eprint/1551219 |
Archive Staff Only
View Item |