Osagie-Clouard, L;
Sanghani, A;
Coathup, M;
Briggs, T;
Bostrom, M;
Blunn, G;
(2017)
Parathyroid hormone 1-34 and skeletal anabolic action: The use of parathyroid hormone in bone formation.
Bone & Joint Research
, 6
(1)
pp. 14-21.
10.1302/2046-3758.61.BJR-2016-0085.R1.
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Abstract
Intermittently administered parathyroid hormone (PTH 1-34) has been shown to promote bone formation in both human and animal studies. The hormone and its analogues stimulate both bone formation and resorption, and as such at low doses are now in clinical use for the treatment of severe osteoporosis. By varying the duration of exposure, parathyroid hormone can modulate genes leading to increased bone formation within a so-called ‘anabolic window’. The osteogenic mechanisms involved are multiple, affecting the stimulation of osteoprogenitor cells, osteoblasts, osteocytes and the stem cell niche, and ultimately leading to increased osteoblast activation, reduced osteoblast apoptosis, upregulation of Wnt/β-catenin signalling, increased stem cell mobilisation, and mediation of the RANKL/OPG pathway. Ongoing investigation into their effect on bone formation through ‘coupled’ and ‘uncoupled’ mechanisms further underlines the impact of intermittent PTH on both cortical and cancellous bone. Given the principally catabolic actions of continuous PTH, this article reviews the skeletal actions of intermittent PTH 1-34 and the mechanisms underlying its effect.
Type: | Article |
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Title: | Parathyroid hormone 1-34 and skeletal anabolic action: The use of parathyroid hormone in bone formation |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1302/2046-3758.61.BJR-2016-0085.R1 |
Publisher version: | http://dx.doi.org/10.1302/2046-3758.61.BJR-2016-00... |
Language: | English |
Additional information: | Copyright © 2017 Osagie-Clouard et al. This is an open-access article distributed under the terms of the Creative Commons Attributions licence (CC-BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, but not for commercial gain, provided the original author and source are credited. |
Keywords: | Parathyroid hormone, Bone formation, Anabolic |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
URI: | https://discovery.ucl.ac.uk/id/eprint/1551025 |
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