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ARACHNE: A neural-neuroglial network builder with remotely controlled parallel computing

Aleksin, SG; Zheng, K; Rusakov, DA; Savtchenko, LP; (2017) ARACHNE: A neural-neuroglial network builder with remotely controlled parallel computing. PLoS Computational Biology , 13 (3) , Article e1005467. 10.1371/journal.pcbi.1005467. Green open access

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Abstract

Creating and running realistic models of neural networks has hitherto been a task for computing professionals rather than experimental neuroscientists. This is mainly because such networks usually engage substantial computational resources, the handling of which requires specific programing skills. Here we put forward a newly developed simulation environment ARACHNE: it enables an investigator to build and explore cellular networks of arbitrary biophysical and architectural complexity using the logic of NEURON and a simple interface on a local computer or a mobile device. The interface can control, through the internet, an optimized computational kernel installed on a remote computer cluster. ARACHNE can combine neuronal (wired) and astroglial (extracellular volume-transmission driven) network types and adopt realistic cell models from the NEURON library. The program and documentation (current version) are available at GitHub repository https://github.com/LeonidSavtchenko/Arachne under the MIT License (MIT).

Type: Article
Title: ARACHNE: A neural-neuroglial network builder with remotely controlled parallel computing
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pcbi.1005467
Publisher version: https://doi.org/10.1371/journal.pcbi.1005467
Language: English
Additional information: Copyright: © 2017 Aleksin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: https://discovery.ucl.ac.uk/id/eprint/1551007
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