UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Haemodynamic changes with paracetamol in critically-ill children

Ray, S; Brick, T; Raman, S; Birrell, PJ; Klein, NJ; Peters, MJ; (2017) Haemodynamic changes with paracetamol in critically-ill children. Journal of Critical Care , 40 pp. 108-112. 10.1016/j.jcrc.2017.03.026. Green open access

[thumbnail of Klein_manuscript_JCC_ed.pdf]
Preview
Text
Klein_manuscript_JCC_ed.pdf - Accepted Version

Download (400kB) | Preview

Abstract

PURPOSE: Paracetamol has been associated with a reduction in blood pressure, especially in febrile, critically-ill adults. We hypothesised that blood pressure would fall following administration of paracetamol in critically-ill children and this effect would be greater during fever and among children with a high body surface area to weight ratio. METHODS: A 12-month prospective observational study of children (0-16years) admitted to paediatric intensive care, who underwent pulse contour analysis and received paracetamol concurrently. RESULTS: Mean arterial blood pressure decreased significantly by 4.7% from baseline (95% CI 1.75-8.07%) in 31 children following 148 doses of paracetamol. The nadir was 2-hour post-dose. The effect was pronounced in children with fever at baseline (6.4%, 95% CI 2.8-10%), although this was not statistically significant. There was no simple relationship between this effect and body surface area to weight ratio. The association between a change in blood pressure and changes in heart rate or measured stroke volume was poor; therefore it was likely that a change in the systemic vascular resistance contributes most to this effect. CONCLUSION: There is a significant but modest reduction in blood pressure post-paracetamol in critically-ill children. This is likely related to a change in systemic vascular resistance.

Type: Article
Title: Haemodynamic changes with paracetamol in critically-ill children
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jcrc.2017.03.026
Publisher version: http://dx.doi.org/10.1016/j.jcrc.2017.03.026
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Child, Critical care, Fever, Paracetamol, Physiologic monitoring
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1550318
Downloads since deposit
230Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item