Michail, M;
Serruys, P;
Stettler, R;
Crake, T;
Torii, R;
Tenekecioglu, E;
Zeng, Y;
... Bourantas, CV; + view all
(2017)
Intravascularmultimodality imaging: feasibility and role in the evaluation of coronary plaque pathology.
European Heart Journal - Cardiovascular Imaging
, 18
(6)
pp. 613-620.
10.1093/ehjci/jew330.
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Abstract
Coronary artery disease remains the leading cause of death in the developed world. Over recent years, research has been focused on the development of diagnostic intravascular imaging techniques that enable assessment of plaque composition and morphology, and allow identification of vulnerable, high-risk lesions. Nevertheless recent studies of coronary atherosclerosis have shown that invasive modalities have a limited accuracy in detecting lesions that will progress and cause events, whilst histology-based studies also highlighted the limitations of invasive imaging in assessing plaque characteristics. To overcome these drawbacks, multimodality imaging has been proposed. Although it is apparent that coronary imaging with two or three imaging modalities is time consuming and is associated with a risk of complications, evidence from small clinical studies demonstrated that it provides incremental information about plaque pathology and biology and underscored the need to develop dual-probe hybrid imaging catheters that would enable complete and comprehensive assessment of plaque morphology. This paper reviews the current clinical evidence that supports the use of multimodality intravascular imaging in the study of atherosclerosis, summarizes the key findings of the first invasive imaging studies that utilize hybrid dual-probe catheters, and discusses the limitations of combined intravascular imaging that restrict its broad application in both the clinical and research arena.
| Type: | Article |
|---|---|
| Title: | Intravascularmultimodality imaging: feasibility and role in the evaluation of coronary plaque pathology |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/ehjci/jew330 |
| Publisher version: | http://dx.doi.org/10.1093/ehjci/jew330 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Multimodality imaging, atherosclerosis, vulnerable plaque, OPTICAL COHERENCE TOMOGRAPHY, NEAR-INFRARED SPECTROSCOPY, ELEVATION MYOCARDIAL-INFARCTION, THIN-CAP FIBROATHEROMA, IN-VIVO, INTEGRATED BIOMARKER, COMBINED IVUS, ULTRASOUND, OCT, ATHEROSCLEROSIS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1549986 |
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