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Intravascularmultimodality imaging: feasibility and role in the evaluation of coronary plaque pathology

Michail, M; Serruys, P; Stettler, R; Crake, T; Torii, R; Tenekecioglu, E; Zeng, Y; ... Bourantas, CV; + view all (2017) Intravascularmultimodality imaging: feasibility and role in the evaluation of coronary plaque pathology. European Heart Journal - Cardiovascular Imaging , 18 (6) pp. 613-620. 10.1093/ehjci/jew330. Green open access

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Abstract

Coronary artery disease remains the leading cause of death in the developed world. Over recent years, research has been focused on the development of diagnostic intravascular imaging techniques that enable assessment of plaque composition and morphology, and allow identification of vulnerable, high-risk lesions. Nevertheless recent studies of coronary atherosclerosis have shown that invasive modalities have a limited accuracy in detecting lesions that will progress and cause events, whilst histology-based studies also highlighted the limitations of invasive imaging in assessing plaque characteristics. To overcome these drawbacks, multimodality imaging has been proposed. Although it is apparent that coronary imaging with two or three imaging modalities is time consuming and is associated with a risk of complications, evidence from small clinical studies demonstrated that it provides incremental information about plaque pathology and biology and underscored the need to develop dual-probe hybrid imaging catheters that would enable complete and comprehensive assessment of plaque morphology. This paper reviews the current clinical evidence that supports the use of multimodality intravascular imaging in the study of atherosclerosis, summarizes the key findings of the first invasive imaging studies that utilize hybrid dual-probe catheters, and discusses the limitations of combined intravascular imaging that restrict its broad application in both the clinical and research arena.

Type: Article
Title: Intravascularmultimodality imaging: feasibility and role in the evaluation of coronary plaque pathology
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/ehjci/jew330
Publisher version: http://dx.doi.org/10.1093/ehjci/jew330
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Multimodality imaging, atherosclerosis, vulnerable plaque, OPTICAL COHERENCE TOMOGRAPHY, NEAR-INFRARED SPECTROSCOPY, ELEVATION MYOCARDIAL-INFARCTION, THIN-CAP FIBROATHEROMA, IN-VIVO, INTEGRATED BIOMARKER, COMBINED IVUS, ULTRASOUND, OCT, ATHEROSCLEROSIS
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1549986
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