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Tissue-Engineered Larynx: Future Applications in Laryngeal Cancer

Hamilton, NJI; Birchall, MA; (2017) Tissue-Engineered Larynx: Future Applications in Laryngeal Cancer. Current Otorhinolaryngology Reports , 5 (1) pp. 42-48. 10.1007/s40136-017-0144-6. Green open access

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Abstract

PURPOSE OF REVIEW: This article reviews the latest developments in tissue engineering for the larynx with a specific focus on the treatment of laryngeal cancer. RECENT FINDINGS: Challenges in tissue engineering a total larynx can be divided into scaffold design, methods of re-mucosalization, and how to restore laryngeal function. The literature described a range of methods to deliver a laryngeal scaffold including examples of synthetic, biomimetic, and biological scaffolds. Methods to regenerate laryngeal mucosa can be divided into examples that use a biological dressing and those that engineer a new mucosal layer de novo. Studies aiming to restore laryngeal function have been reported, but to date, the optimum method for achieving this as part of a total laryngeal transplant is yet to be determined. SUMMARY: There is great potential for tissue engineering to improve the treatments available for laryngeal cancer within the next 10 years. A number of challenges exist however and advances in restoring function must keep pace with developments in scaffold design.

Type: Article
Title: Tissue-Engineered Larynx: Future Applications in Laryngeal Cancer
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s40136-017-0144-6
Publisher version: http://dx.doi.org/10.1007/s40136-017-0144-6
Language: English
Additional information: © The Author(s) 2017. This article is published with open access at Springerlink.com
Keywords: Laryngeal cancer, Larynx, Larynx transplant, Regenerative medicine, Tissue engineering
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/1549984
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