UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Chapter 8 - Pluripotent stem cells and their utility in treating photoreceptor degenerations

Aghaizu, ND; Kruczek, K; Gonzalez-Cordero, A; Ali, RR; Pearson, RA; (2017) Chapter 8 - Pluripotent stem cells and their utility in treating photoreceptor degenerations. Progress in Brain Research , 231 pp. 191-223. 10.1016/bs.pbr.2017.01.001.

[thumbnail of Aghaizu_Pluripotent_stem_cells_utility.pdf] Text
Aghaizu_Pluripotent_stem_cells_utility.pdf - Accepted version
Access restricted to UCL open access staff

Download (931kB)

Abstract

Age-related macular degeneration and inherited retinal degenerations represent the leading causes of blindness in industrialized countries. Despite different initiating causes, they share a common final pathophysiology, the loss of the light sensitive photoreceptors. Replacement by transplantation may offer a potential treatment strategy for both patient populations. The last decade has seen remarkable progress in our ability to generate retinal cell types, including photoreceptors, from a variety of murine and human pluripotent stem cell sources. Driven in large part by the requirement for renewable cell sources, stem cells have emerged not only as a promising source of replacement photoreceptors but also to provide in vitro systems with which to study retinal development and disease processes and to test therapeutic agents.

Type: Article
Title: Chapter 8 - Pluripotent stem cells and their utility in treating photoreceptor degenerations
Location: Netherlands
DOI: 10.1016/bs.pbr.2017.01.001
Publisher version: https://doi.org/10.1016/bs.pbr.2017.01.001
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions
Keywords: Blindness, Cones, Embryonic stem cells, Induced pluripotential stem cells, Photoreceptor cells, Retina, Retinal dystrophies, Stem cells, Transplantation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1549978
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item