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Human regulatory B cells in health and disease: therapeutic potential

Mauri, C; Menon, M; (2017) Human regulatory B cells in health and disease: therapeutic potential. Journal of Clinical Investigation , 127 (3) pp. 772-779. 10.1172/JCI85113. Green open access

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Abstract

Regulatory B cells (Bregs) modulate immune responses predominantly, although not exclusively, via the release of IL-10. The importance of human Bregs in the maintenance of immune homeostasis comes from a variety of immune-related pathologies, such as autoimmune diseases, cancers, and chronic infections that are often associated with abnormalities in Breg numbers or function. A continuous effort toward understanding Breg biology in healthy individuals will provide new opportunities to develop Breg immunotherapy that could prove beneficial in treating various immune-mediated pathologies. In this Review, we discuss findings regarding human Bregs, including their mechanisms of suppression and role in different disease settings. We also propose several therapeutic strategies targeting Bregs for better management of immune disorders.

Type: Article
Title: Human regulatory B cells in health and disease: therapeutic potential
Open access status: An open access version is available from UCL Discovery
DOI: 10.1172/JCI85113
Publisher version: http://dx.doi.org/10.1172/JCI85113
Language: English
Additional information: This is the published version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/1549262
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