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A Developmental Switch in Place Cell Accuracy Coincides with Grid Cell Maturation

Muessig, L; Hauser, J; Wills, TJ; Cacucci, F; (2015) A Developmental Switch in Place Cell Accuracy Coincides with Grid Cell Maturation. Neuron , 86 (5) pp. 1167-1173. 10.1016/j.neuron.2015.05.011. Green open access

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Abstract

Place cell firing relies on information about self-motion and the external environment, which may be conveyed by grid and border cells, respectively. Here, we investigate the possible contributions of these cell types to place cell firing, taking advantage of a developmental time window during which stable border cell, but not grid cell, inputs are available. We find that before weaning, the place cell representation of space is denser, more stable, and more accurate close to environmental boundaries. Boundary-responsive neurons such as border cells may, therefore, contribute to stable and accurate place fields in pre-weanling rats. By contrast, place cells become equally stable and accurate throughout the environment after weaning and in adulthood. This developmental switch in place cell accuracy coincides with the emergence of the grid cell network in the entorhinal cortex, raising the possibility that grid cells contribute to stable place fields when an organism is far from environmental boundaries.

Type: Article
Title: A Developmental Switch in Place Cell Accuracy Coincides with Grid Cell Maturation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2015.05.011
Publisher version: https://doi.org/10.1016/j.neuron.2015.05.011
Language: English
Additional information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, MEDIAL ENTORHINAL CORTEX, SPATIAL PERIODICITY, GEOMETRIC BORDERS, PATH-INTEGRATION, FIRING FIELDS, COGNITIVE MAP, RAT, MODEL, REPRESENTATION, NAVIGATION
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/1549259
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