Astarita, JL;
Acton, SE;
Turley, SJ;
(2012)
Podoplanin: emerging functions in development the immune system and cancer.
Frontiers in Immunology
, 3
, Article 283. 10.3389/fimmu.2012.00283.
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Abstract
Podoplanin (PDPN) is a well-conserved, mucin-type transmembrane protein expressed in multiple tissues during ontogeny and in adult animals, including the brain, heart, kidney, lungs, osteoblasts, and lymphoid organs. Studies of PDPN-deficient mice have demonstrated that this molecule plays a critical role in development of the heart, lungs, and lymphatic system. PDPN is widely used as a marker for lymphatic endothelial cells and fibroblastic reticular cells of lymphoid organs and for lymphatics in the skin and tumor microenvironment. Much of the mechanistic insight into PDPN biology has been gleaned from studies of tumor cells; tumor cells often upregulate PDPN as they undergo epithelialmesenchymal transition and this upregulation is correlated with increased motility and metastasis.The physiological role of PDPN that has been most studied is its ability to aggregate and activate CLEC-2-expressing platelets, as PDPN is the only known endogenous ligand for CLEC-2. However, more recent studies have revealed that PDPN also plays crucial roles in the biology of immune cells, includingT cells and dendritic cells.This review will provide a comprehensive overview of the diverse roles of PDPN in development, immunology, and cancer.
| Type: | Article |
|---|---|
| Title: | Podoplanin: emerging functions in development the immune system and cancer |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fimmu.2012.00283 |
| Publisher version: | http://dx.doi.org/10.3389/fimmu.2012.00283 |
| Language: | English |
| Additional information: | © 2012 Astarita, Acton and Turley. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Immunology, podoplanin, CLEC-2, lymph node stromal cells, lymphatic endothelial cells, platelets, cancer-associated fibroblasts |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1548631 |
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